272.09 Molecular Weight Zoledronic Acid CAS 118072-93-8 CGP-42446

Basic Information
Place of Origin: CHINA
Brand Name: MOSINTER
Certification: COA
Model Number: Antineoplastic Drugs API - 19
Minimum Order Quantity: 1KG
Price: Negotiation
Packaging Details: Aluminum foil bag,kraft paper bag
Delivery Time: Within 7 days
Payment Terms: L/C, T/T
Supply Ability: Can be customized according to customer requirements
Detail Information
Name: Zoledronic Acid CAS: 118072-93-8
Form: Powder Molecular Formula: C5H10N2O7P2
Molecular Weight: 272.09 Usage: Antineoplastic Drugs API
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Product Description

Zoledronic acid CAS 118072-93-8 CGP-42446 Pharmaceutical Grade Chemicals




Zoledronic acid monohydrate is white powder, tasteless, easy to melt in sodium hydroxide solution, slightly soluble in water, insoluble in methanol, ethanol, dichloromethane.Melting point 237 ℃ to 240 ℃.Zoledronic acid has alkaloid structure and can form orange precipitate with bismuth potassium iodide.Add 20mg of this product into 20m L of water, pH=2.0-3.5.





A white or almost white crystalline powder




C) UV-Vis: There is a maximum absorbance at 210nm


2.0 ~ 3.0

Clarity and color

Comply with requirements

Loss on drying

5.0% ~ 7.0%





Heavy metals




Related substances

Individual impurity≤0.25%

Total impurities≤0.5%


98.0% ~ 102.0%




1) malignant hypercalcemia: hypercalcemia is a metabolic complication of malignant tumors. When serum calcium in the body is higher than 3.75mmol/L, hypercalcemia crisis may occur, which may eventually cause death.Zoledronic acid does

Hypercalcemia is treated by inhibiting bone absorption, reducing blood calcium levels and increasing urinary calcium excretion.Zoledronic acid was given to 14 patients with neoplastic hypercalc, and the final results showed that zoledronic acid corrected the serum calcium to 100% during the observation period, the median effective remission time was 5.07d, and the median remission maintenance time was 22.30d.Studies have shown that 4 mg zoledronic acid is recommended for the initial dose of hypercalcemia, and 8mg zoledronic acid is recommended for recurrent or refractory hypercalcemia.

2) bone metastasis: zoledronic acid is a new generation of powerful nitrophosphonates, which has been used in the treatment of multiple myeloma, breast cancer, lung cancer and other complications related to bone metastasis in foreign clinical practice.


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