|Place of Origin:||CHINA|
|Model Number:||Antibiotic Drugs API - 14|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Aluminum foil bag , kraft paper bag|
|Delivery Time:||Within 7 days|
|Payment Terms:||L/C, T/T|
|Supply Ability:||Can be customized according to customer requirements|
|Molecular Weight:||247.25||Melting Point:||136-140°C|
pharmaceutical raw materials,
raw material for medicine manufacturing
Emtricitabine CAS 143491-57-0 C8H10FN3O3S Pharmaceutical Grade Chemicals
By the Gilead Siences company successfully developed a new type of nuclear nucleoside reverse transcriptase inhibitors, antiviral drugs, on HIV, HIV - 1-2 and has antiviral activity, HBV antiviral activity in its specificity to HIV - 1, 2 and HBV, HIV - and its drug concentration to mnol 100 / L, also did not see it on HSV - 1, 2, HCMV, VZV HSV -, corona, yellow fever virus, respiratory syncytial virus, Rota, or nasal influenza virus virus activity.Even lower than the molar concentration, the drug also showed the LAV and Ⅲ B strains of HIV 1 and HIV - 2 ROD2 and potent inhibition of ZY strains, the IC50 alue concentration is lower than AZT (zidovudine) 95 times.
|Description||A white or almost white crystalline powder||white crystalline powder|
Freely soluble in Methanol and Water; Practically insoluble in
The infrared absorption spectrum is
concordant with the spectrum
obtained from Emtricitabine RS or
with the reference spectrum of
Limit of Emtricitabine
|Loss on Drying||≤0.5% (3 hours at 105°C)||0.14%|
|Residue on Ignition||≤0.1%||Complies|
|Total impurities ≤1.0%||0.10%|
|Residual Solvents||Ethanol ≤0.30%||0.14%|
|Dichloromethane ≤ 0.06%||Not detected|
|DMF ≤ 0.088%||Not detected|
|Triethylamine ≤ 0.032%||Not detected|
|Toluene NMT 0.089%||Not detected|
|Conclusion||Meets the Requirements|
This product is a novel nucleoside reverse transcriptase inhibitor for HIV-
1. Both hiv-2 and HBV have antiviral activity.After oral administration, it is phosphorylated into the cell active 5 '-triphosphate, and 5' -triphosphate enters the viral DNA main chain and binds with the main chain, leading to the termination of the chain, thus inhibiting the activity of hiv-1 reverse transcriptase and HBV DNA polymerase.It is used in combination with other antiretrovirals for the treatment of adults with hiv-1 (AIDS) and hepatitis b.
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