|Place of Origin:||CHINA|
|Model Number:||Antibiotic Drugs API - 35|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Aluminum foil bag , kraft paper bag|
|Delivery Time:||Within 7 days|
|Payment Terms:||L/C, T/T|
|Supply Ability:||Can be customized according to customer requirements|
|Molecular Weight:||137.14||Melting Point:||171-173 °C(lit.)|
pharmaceutical raw materials,
raw material for medicine manufacturing
Isoniazid CAS 54-85-3 Isonicotinic acid hydrazide Pharmaceutical Grade Chemicals
Isoniazid, colorless crystal, or white to white crystalline powder;No smell, taste slightly sweet after bitter;Light gradually deteriorated.This product is soluble in water, slightly soluble in ethanol and extremely slightly soluble in ether.Melting point the melting point of this product is 170 ~ 173℃.The invention of isoniazid in 1952 revolutionized the treatment of tuberculosis.In its nearly 50-year history, the vast majority of doctors still regard TB as an indispensable drug, although some patients have developed resistance to the bacterium.Rifampicin, ethambutol, sterptomycin and pyrazinamide are first-line antituberculosis drugs.
|Characters||A white crystalline powder or colorless crystals||A white crystalline powder|
|Hydrazine and related substances||Conforms||Conforms|
|Loss on drying||≤0.5%||0.11%|
It can inhibit and kill mycobacterium tuberculosis, and has good biofilm penetration. Due to its good efficacy, low toxicity, low price and convenient oral administration, it is listed as the first choice of anti-tuberculosis drugs. the oral absorption rate of isoniazid was 90%;The serum drug concentration reached the peak 1 ~ 2 hours after taking.Vd is 0.61 + 0.11L/kg, protein binding rate is very low.The product is mainly metabolized by acetylation and partial hydrolysis in vivo.Due to genetic differences, the population can be divided into fast acetylation and slow acetylation.Their half-lives were significantly different, with the average for fast acetylators being 1 half.1 hour.Slow acetylation was 3 hours.The product easily crosses the blood-brain barrier.It is mainly used in the progressive stage, dissolution spreading stage and absorption improvement stage of various types of tuberculosis, and can also be used in tuberculous meningitis and other tuberculosis outside the lung.It is often used in combination with other anti-tb drugs to enhance efficacy and overcome drug-resistant bacteria.In addition to dysentery, pertussis, sty and so have a certain effect.
Isoniazid was also the first antidepressant, but was withdrawn from the market because of its strong liver toxicity.
Isoniazid is highly selective to mycobacterium tuberculosis and has strong antibacterial effect. The concentration of 0.025 ~ 0.05mg/L in the test tube can inhibit bacteria, and the higher concentration of 10mg/L has bactericidal effect on bacteria in the breeding stage.To the tuberculosis bacili of quiescent period, raise medicaments concentration or prolong contact time to also can have bactericidal effect.It has the same killing effect on the tuberculosis bacillus inside and outside the cell.Isoniazid is easy to develop drug resistance, and the combination of drugs can delay the emergence of drug resistance and enhance the efficacy.There was no cross - resistance between isoniazid and other anti - tuberculosis drugs.
Although the mechanism of isoniazid action has been studied in detail, it is not very clear.One theory is that isoniazid is converted to iso-nicotinic acid, which ACTS as an anti-metabolite of nicotinic acid and binds to NAD+ in place of nicotinic acid. The tricked NAD+ does not catalyze normal REDOX reactions.Another theory is that by blocking an enzyme to saturation, isoniazid suppression C24 and C26 saturated fatty acid to C24 C26 and unsaturated fatty acids, the unsaturated fatty acid was likely mold acid precursors, mold acid is a key component of bacterial cell walls, inhibitory acid biosynthesis, makes the loss of bacterial resistance to acid, this mechanism fully illustrates the isoniazid selective effect on the cell walls of mycobacterium tuberculosis.
This article is the drug of first choice that treats tuberculosis, apply to all sorts of tuberculosis, wait for tuberculosis such as lung, lymphatic, bone, kidney, bowel, meningitis of tuberculosis sex, pleurisy and peritonitis.In order to prevent and delay the emergence of drug resistance, it should be combined with other first-line anti-tb drugs.For acute miliary tuberculosis and tuberculous meningitis, doses should be increased and intravenous drip should be used when necessary.Isoniazid can be used to prevent contact with people with active pulmonary nodules.
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