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Mildronate CAS 76144-81-5 C6H14N2O2 Pharmaceutical Grade Chemicals

Basic Information
Place of Origin: CHINA
Brand Name: MOSINTER
Certification: COA
Model Number: Circulatory System Drugs API - 11
Minimum Order Quantity: 1KG
Price: Negotiation
Packaging Details: Aluminum foil bag , kraft paper bag
Delivery Time: Within 7 days
Payment Terms: L/C, T/T
Supply Ability: Can be customized according to customer requirements
Detail Information
Name: Mildronate CAS: 76144-81-5
Form: Powder Molecular Formula: C6H14N2O2
Molecular Weight: 146.18756 Melting Point: 85-90 °C
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Product Description

Mildronate CAS 76144-81-5 C6H14N2O2 Pharmaceutical Grade Chemicals
 

Description:

 

Meldonium (also known as THP, met-88 and mildronate) is a new heart protective drug.Developed by latovia organic synthesis, first marketed in the former Soviet union in 1989 by Grindeks, it is a structural analogue of carnitine, chemically known as 3- (2, 2, 2-trimethylenehydrazol) propionate dihydrate.It has been registered and listed in more than 20 countries, including Russia, Turkey, India and Romania.


Specifications:
 

ITEM
STANDARD
RESULTS
Appearance
White or almost white crystalline powder
White crystalline powder
Dissolution
Easily solubale in water, solubale in 95% alcohol
Complies
Indentification
(1) Should be positive respond
(2) IR graphs should be conforms to the reference standard
Complies
pH
7.0~9.0
7.94
Clarity
should be not more than 1# working standard solution
Complies
Color
Should be lighter than the standard solution
Complies
Optical transmission
Not less than 95%
99.2%
Water
19.0~21.0%
19.66%
Chlorides
Not more than 0.01%
Complies


Application: 
 

Meldonium acts on mitochondria at the cellular level to improve myocardial energy metabolism. In view of these drugs and other anti-myocardial ischemia significantly different, also known as cell anti-ischemic drugs.

Meldonium is a structural analog of carnitine that competes in the inhibition of butyrate betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine, which directly inhibits the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine and prevent isoproterenol-induced acyl carnitine accumulation. Therefore, the drug has a significant protective effect on the myocardium, resulting in this protective effect at the same time on the hemodynamic parameters had no significant effect, cardiac blood supply and cardiac oxygen consumption was no significant change.


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