|Place of Origin:||CHINA|
|Model Number:||Antibiotic Drugs API - 24|
|Minimum Order Quantity:||1KG|
|Packaging Details:||Aluminum foil bag , kraft paper bag|
|Delivery Time:||Within 7 days|
|Payment Terms:||L/C, T/T|
|Supply Ability:||Can be customized according to customer requirements|
|Molecular Weight:||1189.3426||Melting Point:||217-220°C (dec.)|
pharmaceutical raw materials,
raw material for medicine manufacturing
Polymyxin B CAS 1405-20-5 Polymyxin B sulfate Pharmaceutical Grade Chemicals
Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture composition"). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.
|Description||White or almost white powder, hygroscopic||White powder|
|Identification||LC identification test, Conforms||Conforms|
|A reddish violet color is produced, Conforms|
|Meets the requirements of the test for Sulfate ,Conforms|
|Specific optical rotation||-78°~-90°||-79°|
|Loss on drying||≤6.0%||2.8%|
|Related substances, HPLC||
Any impurity: ≤3.0%
Sum of impurity: ≤17.0%
|Total viable aerobic count||≤100CFU/g||Conforms|
|Potency (Dried basis)||≥6000IU/mg||8204IU/mg|
|Assay HPLC (Dried basis)||
Sum of polymyxin B1, B2, B3 and B1-I:
(Neither USP nor EP has this)
99.0%: Not more than 30µm by vol
90.0%: Not more than 20µm by vol
75.0%: Not more than 15µm by vol
35.0%: Not more than 10µm by vol
Mean diameter: Not more than 15µm
|Conclusion||The results conforms with enterprise standards|
Uses Polymyxin B is an anti-Gram-negative bacillus polypeptide antibiotics, can change the membrane structure of small molecules to leak and inhibit the growth of Gram-negative bacteria. E. coli has a bactericidal effect. Binding to the lipid A fraction of the bacterial lipopolysaccharide. In the skin membrane induced by small holes. Mode of action: to combine and interfere with the plasma membrane permeability. Antibacterial spectrum: Gram-negative bacteria.
Acid polymyxin B and polymyxin E similar to Gram-negative bacilli, such as E. coli, Pseudomonas aeruginosa, Vice E. coli, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella, such as inhibition Or bactericidal action. Mainly used in Pseudomonas aeruginosa and other Pseudomonas caused by the wound, urinary tract and eye, ear, trachea and other parts of infection, can also be used for sepsis, peritonitis. And resistant to aminoglycosides, third-generation cephalosporin-resistant bacteria and Pseudomonas aeruginosa or other susceptible strains caused by severe infections, such as bacteremia, endocarditis, pneumonia, post-burn infection.
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