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Rifabutin CAS 72559-06-9 C46H62N4O11 Pharmaceutical Grade Chemicals

Basic Information
Place of Origin: CHINA
Brand Name: MOSINTER
Certification: COA
Model Number: Antibiotic Drugs API - 32
Minimum Order Quantity: 1KG
Price: Negotiation
Packaging Details: Aluminum foil bag , kraft paper bag
Delivery Time: Within 7 days
Payment Terms: L/C, T/T
Supply Ability: Can be customized according to customer requirements
Detail Information
Name: Rifabutin CAS: 72559-06-9
Form: Powder Molecular Formula: C46H62N4O11
Molecular Weight: 847 Melting Point: 169-171°C
High Light:

chemical raw materials

,

raw material for medicine manufacturing


Product Description

Rifabutin CAS 72559-06-9 C46H62N4O11 Pharmaceutical Grade Chemicals
 
Description:

 

Rifabutin (LM427) is a derivative of rifamycin containing spiperazine group.The mechanism of action is the same as rifampicin, which can form stable binding to the DNA dependent RNA polymerase beta subunit of microorganisms, inhibit the activity of this enzyme, and thus inhibit the synthesis of bacterial RNA.It has been approved to prevent and treat extensively disseminated infection of mycobacterium avium - intracellular mycobacterium complex (MAC) in hiv-infected patients, and to treat multi-drug-resistant tuberculosis.

 

Specifications:

 

Test Items

Standard

Result

Characters

Reddish violet crystalline powder

conforms

Identification

IR/HPLC

conforms

N-isobutylpiperidone

≤0.5%

<0.5%

Chromatographic purity

Individual impurity with RT around0.5/0.6/0.8/1.4

≤1.0%

0.42%

Any other impurity

≤0.5%

0.20%

The sum of all impurities

≤3.0%

1.90%

Water

≤2.5%

1.9%

Assay

95.0%-102.0%

98.0%

Residual organic solvents

Methylene chloride

≤600ppm

38ppm

Cyclohexane

≤3880ppm

N.D

hexane

≤290ppm

N.D

ethanol

≤5000ppm

105ppm

2-methoxyethanol

≤50ppm

9.8ppm

Ethyl acetate

≤5000ppm

N.D

tetrahydrofurane

≤720ppm

N.D

Conclusion

The results conform with USP30 standard

 

Application: 

 

1.Rifabutin is now recommended as first-line treatment for tuberculosis, but Rifampicin is more widely used because of its cheaper cost.
 
2.Rifabutin is used in the treatment of mycobacterium avium complex disease, a bacterial infection most commonly encountered in late-stage AIDS patients. Its main usefulness lies in the fact that it has lesser medicine interactions than rifampicin; therefore HIV infected patients on HAART are usually given rifabutin for treatment of TB.

 

Our strengths:
 
We can customize according to customer's requirement.
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