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Smell Less PeMetrexed DisodiuM 7- Hydrate CAS 357166-29-1 Hygroscopic Freely

Basic Information
Place of Origin: CHINA
Brand Name: MOSINTER
Certification: COA
Model Number: Antineoplastic Drugs API - 17
Minimum Order Quantity: 1KG
Price: Negotiation
Packaging Details: Aluminum foil bag,kraft paper bag
Delivery Time: Within 7 days
Payment Terms: L/C, T/T
Supply Ability: Can be customized according to customer requirements
Detail Information
Name: PeMetrexed DisodiuM 7-hydrate CAS: 357166-29-1
Form: Powder Molecular Formula: C20H19N5Na2O6.7(H2O)
Molecular Weight: 597 Usage: Antineoplastic Drugs API
High Light:

pharmaceutical raw materials

,

raw material for medicine manufacturing


Product Description

PeMetrexed disodiuM 7-hydrate CAS 357166-29-1 Pharmaceutical Grade Chemicals
 
Description:
 
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy medicine called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
 
Specifications:
 

Test Items

Standard

Test Results

Character

Almost-white powder, smell-less, hygroscopic freely.

white powder, smell-less, hygroscopic freely.

Solubility

Soluble in water very freely, hardly soluble in ethanol or chloroform or ethyl ether.

Conforms

Specific optical rotation

+10°-+16°

+12.0°

Identification

(1)The product appears flame reaction of sodium salt.
(2)UV:Max absorption at 225nm wavelength.
(3)IR:Meet the requirements.

Conform
 
Conform
Meet the requirements.

PH

6.5-8.5

7.2

Clarity and color of solution

Meet the requirements.

Conforms

Related substance

Max single impurity≤0.1%

0.036%

Total impurity≤0.5%

0.17%

Heavy Metal

<20ppm

Conforms

Water

7.2%-10.2%

8.8%

Ethanol

≤5000ppm

1687ppm

Purity

≥99.5%

99.83%

 
Application:
 
An organic sodium salt that is the heptahydrate form of pemetrexed disodium. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
 
Our strengths:
 
We can customize according to customer's requirement.
If you have any question pls mail us or call us.
 
 
 

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